3,3-二甲基-5-氟氧化吲哚合成路线 （共 2 条）
反应条件
hydrogenchloride; water in isopropyl alcohol
1 h; Reflux;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2012/149698 A1, 2012 ;
Location in patent: Page/Page column 24 ;
反应条件
1: 5-Fluoro-1,3-dihydro-2H-indol-2-one With n-butyllithium; lithium chloride in tetrahydrofuran; hexane
T=0°C; 0.333333 h;
2: methyl iodide in tetrahydrofuran; hexane
T=0 - 20°C; 18 h;
参考文献
Vu, An T.; Cohn, Stephen T.; Zhang, Puwen; Kim, Callain Y.; Mahaney, Paige E.; Bray, Jenifer A.; Johnston, Grace H.; Koury, Elizabeth J.; Cosmi, Scott A.; Deecher, Darlene C.; Smith, Valerie A.; Harrison, James E.; Leventhal, Liza; Whiteside, Garth T.; Kennedy, Jeffrey D.; Trybulski, Eugene J.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 5 p. 2051 - 2062
