4-(3-溴-苯基)-3-氧代-丁酸乙酯合成路线 （共 5 条）
反应条件
1: malonic acid ethyl ester monopotassium salt With triethylamine; magnesium chloride in acetonitrile
3 h;
2: 2-(3-Bromo-phenyl)-acetic acid With 1,1'-carbonyldiimidazole in acetonitrile
T=18 - 25°C; 18.5 h; Heating / reflux;
参考文献
ASTRAZENECA AB; ASTEX THERAPEUTICS
Patent: WO2006/41405 A1, 2006 ;
Location in patent: Page/Page column 98-99; 144-145 ;
WO 2006/041405 A1
反应条件
tin(ll) chloride in dichloromethane
4 h;
参考文献
Davies, James R.; Kane, Peter D.; Moody, Christopher J.
Journal of Organic Chemistry, 2005 , vol. 70, # 18 p. 7305 - 7316
反应条件
1: LiAlH4 / diethyl ether / 0.5 h / 0 °C
2: 71 percent / SnCl2 / CH2Cl2 / 4 h
View Scheme
参考文献
Davies, James R.; Kane, Peter D.; Moody, Christopher J.
Journal of Organic Chemistry, 2005 , vol. 70, # 18 p. 7305 - 7316
反应条件
1: 4.9 g / Et3N / CH2Cl2 / 20 °C
2: LiAlH4 / diethyl ether / 0.5 h / 0 °C
3: 71 percent / SnCl2 / CH2Cl2 / 4 h
View Scheme
参考文献
Davies, James R.; Kane, Peter D.; Moody, Christopher J.
Journal of Organic Chemistry, 2005 , vol. 70, # 18 p. 7305 - 7316
反应条件
1: 95 percent / DIBAL-H / CH2Cl2; toluene / 0.67 h / -78 °C
2: 71 percent / SnCl2 / CH2Cl2 / 4 h
View Scheme
参考文献
Davies, James R.; Kane, Peter D.; Moody, Christopher J.
Journal of Organic Chemistry, 2005 , vol. 70, # 18 p. 7305 - 7316
