5-氟-1-[(4-甲基苯基)磺酰基]-1H-吡咯并[2,3-b]吡啶合成路线 （共 2 条）
反应条件
sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate in water; toluene
T=20°C; 24 h;
参考文献
Aventis Pharma S.A.
Patent: US2007/93480 A1, 2007 ;
Location in patent: Page/Page column 44 ;
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane
T=-78 - -75°C; 1 h;
2: With iodine in tetrahydrofuran; hexane
T=20°C;
参考文献
Nemecek, Conception; Metz, William A.; Wentzler, Sylvie; Ding, Fa-Xiang; Venot, Corinne; Souaille, Catherine; Dagallier, Anne; Maignan, Sebastien; Guilloteau, Jean-Pierre; Bernard, Francois; Henry, Alain; Grapinet, Sandrine; Lesuisse, Dominique
Chemical Biology and Drug Design, 2010 , vol. 76, # 2 p. 100 - 106
