5-氟-3-((三甲基甲硅烷基)乙炔)吡啶-2-胺合成路线 （共 3 条）
反应条件
potassium tert-butylate in 1-methyl-pyrrolidin-2-one T=130°C; 4 h;
参考文献
AVENTIS PHARMA S.A.
Patent: US2008/45561 A1, 2008 ;
Location in patent: Page/Page column 30 ;
反应条件
copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl-formamide
T=50°C; 8 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/4117 A1, 2008 ;
Location in patent: Page/Page column 105 ;
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
T=20°C; 1 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/4117 A1, 2008 ;
Location in patent: Page/Page column 105 ;
