1: With thionyl chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene in isopropanol acetate T=20 - 30°C; 18.5 h; 2: With hydroxylamine in tetrahydrofuran; isopropanol acetate; water T=0 - 10°C; 3: With hydrogenchloride in tetrahydrofuran; isopropanol acetate; water T=0 - 30°C; 1 h;

1: With hydroxylamine hydrochloride; potassium hydroxide in ethanol T=0°C; 1 h; 2: With hydrogenchloride in ethanol; water

1.1: 74 percent / NaHCO3 / dioxane; H2O / 1 h / 20 °C 2.1: 85 percent / NaOH / H2O; methanol / 20 °C 3.1: (COCl)2; DMF / CH2Cl2 / 1 h / Heating 3.2: 85 percent / hydroxylamine hydrochloride; NaHCO3 / tetrahydrofuran; H2O / 1 h / 20 °C View Scheme

1.1: 51 percent / oleum / 10 h / 40 °C 2.1: 55 percent / K2CO3 / H2O / 0.5 h / 20 °C 3.1: 82 percent / SOCl2 / benzene; dimethylformamide / 5 h / Heating 4.1: 74 percent / NaHCO3 / dioxane; H2O / 1 h / 20 °C 5.1: 85 percent / NaOH / H2O; methanol / 20 °C 6.1: (COCl)2; DMF / CH2Cl2 / 1 h / Heating 6.2: 85 percent / hydroxylamine hydrochloride; NaHCO3 / tetrahydrofuran; H2O / 1 h / 20 °C View Scheme