1: 85 percent / tetramethylurea; AgOTf / CH2Cl2 / 12 h / 20 °C 2: 52 percent / copper(II) acetate; lithium acetate; palladium(II) acetate / dimethylformamide / 1 h / 100 °C 3: 86 percent / NaOMe / methanol; tetrahydrofuran / 1 h / 20 °C View Scheme

1: [bis(acetoxy)iodo]benzene; 2,2,6,6-tetramethyl-piperidine-N-oxyl / acetonitrile; water / 5 h 2: sodium hydrogencarbonate / N,N-dimethyl-formamide 3: palladium dichloride / dichloromethane; methanol / 16 h / 20 °C 4: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 5 h / |Cooling with ice View Scheme