1: 2-bromo-5-phenyl-pyridine With n-butyllithium in diethyl ether; hexane T=-60°C; 2 h; 2: N,N-dimethyl acetamide in diethyl ether; hexane 2 h; 3: With hydrogenchloride; water in diethyl ether; hexane T=20°C;

tetrakis(triphenylphosphine) palladium(0); potassium carbonate in water; toluene T=105°C; Suzuki reaction; Inert atmosphere;

1.1: n-butyllithium / toluene / Inert atmosphere 1.2: Inert atmosphere 2.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / water; toluene / 105 °C / Inert atmosphere View Scheme