反应条件
1.1: 93 percent / DMAP; EDC; Et3N / CH2Cl2 / 31 h / 0 - 20 °C
2.1: aq. TFA / CH2Cl2 / 0 - 20 °C
3.1: 77 percent / HATU; DIPEA / dimethylformamide / 1.5 h / 0 - 20 °C
4.1: (CH3O)3CH; PPTS / CH2Cl2 / 2 h / 20 °C
4.2: AcBr / CH2Cl2 / 4 h / 20 °C
4.3: 72 percent / KHCO3; (nBu)4NBr / 1,2-dimethoxy-ethane / 27 h / 40 °C
View Scheme
参考文献
Mast, Christian Alexander; Eissler, Stefan; Stoncius, Arvydas; Stammler, Hans-Georg; Neumann, Beate; Sewald, Norbert
Chemistry - A European Journal, 2005 , vol. 11, # 16 p. 4667 - 4677
