7-乙基-10-羟基喜树碱合成路线 （共 84 条）
反应条件
2: 92 percent / OsO4, Me3NO*2H2O / 2-methyl-propan-2-ol / 24 h / 40 °C 3: 76 percent / PS-30 catalyst / various solvent(s) / 48 h 4: 100 percent / NaOCl, 4-acetoxy-TEMPO, KBr, NaHCO3 / CH2Cl2; H2O / 0.67 h 5: 96 percent / H2 / Pd/C / methanol / 96 h / 775.7 Torr / Ambient temperature; other catalyst, reaction time, temperature 6: 99 percent / TEMPO, KBr, NaHCO3, NaOCl / CH2Cl2; H2O / 0.5 h 7: 89 percent / TMSCl, NaI / acetonitrile / 6 h / 0 - 20 °C 8: 74 percent / Cs2CO3 / dimethylsulfoxide / 21 h / 47 - 50 °C 9: 93.4 percent / trifluoroacetic acid; toluene / 2 h / 110 °C 10: p-TSA*H2O / toluene; acetic acid / 18 h / 95 - 100 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 62, # 19 p. 6588 - 6597
反应条件
1: With Grignard reagent in tetrahydrofuran T=-40 - 0°C; 1.25 - 1.5 h; 2: With oxygen in tetrahydrofuran 3: With hydrogenchloride; sodium hydroxide; water Product distribution / selectivity; more than 3 stages;
参考文献
US2005/272757 A1, ;
Page/Page column 13; 4/8 ;
反应条件
sulfuric acid in 1,4-dioxane 0.5 h; Irradiation;
参考文献
Sawada; Okajima; Aiyama; Nokata; Furuta; Yokokura; Sugino; Yamaguchi; Miyasaka
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 6 p. 1446 - 1454
反应条件
sulfuric acid in 1,4-dioxane 0.5 h; Irradiation;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 39, # 12 p. 3183 - 3188
反应条件
1: H2 / Pd/C 2: NaOMe / methanol View Scheme
参考文献
Tetrahedron, , vol. 62, # 11 p. 2465 - 2470
反应条件
1: 67 percent / NaH, LiBr / 1,2-dimethoxy-ethane; dimethylformamide / 1.) 0 deg C, 10 min; r.t., 15 min, 2.) toluene, 70 deg C, 20 h 2: 57 percent / Me6Sn2 / benzene / 5 h / 70 °C / Irradiation 3: 90 percent / aq. HBr / 72 h / 110 °C View Scheme
参考文献
Chemistry - A European Journal, , vol. 4, # 1 p. 67 - 83
反应条件
1: 73 percent / Me3SiCl, NaI / acetonitrile; H2O / 5 h / 65 °C 2: 67 percent / NaH, LiBr / 1,2-dimethoxy-ethane; dimethylformamide / 1.) 0 deg C, 10 min; r.t., 15 min, 2.) toluene, 70 deg C, 20 h 3: 57 percent / Me6Sn2 / benzene / 5 h / 70 °C / Irradiation 4: 90 percent / aq. HBr / 72 h / 110 °C View Scheme
参考文献
Chemistry - A European Journal, , vol. 4, # 1 p. 67 - 83
反应条件
1: 67 percent / NaH, LiBr / 1,2-dimethoxy-ethane; dimethylformamide / 1.) 0 deg C, 10 min; r.t., 15 min, 2.) toluene, 70 deg C, 20 h 2: 57 percent / Me6Sn2 / benzene / 5 h / 70 °C / Irradiation 3: 90 percent / aq. HBr / 72 h / 110 °C View Scheme
参考文献
Chemistry - A European Journal, , vol. 4, # 1 p. 67 - 83
反应条件
1: 57 percent / Me6Sn2 / benzene / 5 h / 70 °C / Irradiation 2: 90 percent / aq. HBr / 72 h / 110 °C View Scheme
参考文献
Chemistry - A European Journal, , vol. 4, # 1 p. 67 - 83
反应条件
1: 45 percent / ICl / CCl4; CH2Cl2 / 48 h / Ambient temperature 2: 73 percent / Me3SiCl, NaI / acetonitrile; H2O / 5 h / 65 °C 3: 67 percent / NaH, LiBr / 1,2-dimethoxy-ethane; dimethylformamide / 1.) 0 deg C, 10 min; r.t., 15 min, 2.) toluene, 70 deg C, 20 h 4: 57 percent / Me6Sn2 / benzene / 5 h / 70 °C / Irradiation 5: 90 percent / aq. HBr / 72 h / 110 °C View Scheme
参考文献
Chemistry - A European Journal, , vol. 4, # 1 p. 67 - 83
