1-(5-溴-1H-吡咯并[2,3-B]吡啶-3-基)-乙酮合成路线 （共 2 条）
反应条件
AlCl3, aluminium chloride in dichloromethane
T=20°C; Friedel Crafts acylation; Inert atmosphere;
参考文献
Hong, Seunghee; Lee, Soyoung; Kim, Bomi; Lee, Hyunseung; Hong, Soon-Sun; Hong, Sungwoo
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 24 p. 7212 - 7215
反应条件
1: 5-Bromo-1H-pyrrolo[2,3-b]pyridine With AlCl3, aluminium chloride in dichloromethane
T=20°C; 1 h;
2: acetyl chloride in dichloromethane
T=20°C; 18 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED?
Patent: WO2005/95400 A1, 2005 ;
Location in patent: Page/Page column 330; 331 ;
WO 2005/095400 A1
