5-氯-1-[(1,1-二甲基乙基)二甲基硅酯]-1H-吡咯并[2,3-B]吡啶合成路线 (共 1 条)
反应条件
1: 5-chloro-1H-pyrrolo[2,3-b]pyridine With sodium hydride in tetrahydrofuran
T=0°C; 0.25 h;
2: tert-butyldimethylsilyl chloride in tetrahydrofuran
T=80°C; 3 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED?
Patent: WO2005/95400 A1, 2005 ;
Location in patent: Page/Page column 342; 343-344 ;
WO 2005/095400 A1