(3aS,4R,6aR)-四氢-4-甲氧基呋喃并[3,4-b]呋喃-2(3H)-酮合成路线 （共 4 条）
反应条件
1: With methanol
T=0 - 5°C; 3 h;
2: With sulfuric acid in methanol
T=0 - 5°C;
参考文献
Quaedflieg, Peter J. L. M.; Kesteleyn, Bart R. R.; Wigerinck, Piet B. T. P.; Goyvaerts, Nicolaas M. F.; Vijn, Robert Jan; Liebregts, Constantinus S. M.; Kooistra, Jaap H. M. H.; Cusan, Claudia
Organic Letters, 2005 , vol. 7, # 26 p. 5917 - 5920
反应条件
1.1: DBU / methanol / 18 h / 20 °C
2.1: MeOH / 3 h / 0 - 5 °C
2.2: aq. H2SO4 / methanol / 0 - 5 °C
View Scheme
参考文献
Quaedflieg, Peter J. L. M.; Kesteleyn, Bart R. R.; Wigerinck, Piet B. T. P.; Goyvaerts, Nicolaas M. F.; Vijn, Robert Jan; Liebregts, Constantinus S. M.; Kooistra, Jaap H. M. H.; Cusan, Claudia
Organic Letters, 2005 , vol. 7, # 26 p. 5917 - 5920
反应条件
sulfuric acid
T=0°C; Nef Reaction; 4.67 h; Product distribution / selectivity;
参考文献
TIBOTEC PHARMACEUTICALS Ltd.
Patent: WO2005/95410 A1, 2005 ;
Location in patent: Page/Page column 40 ;
反应条件
1: With sodium methylate
T=0°C; Michael Condensation; 18 h;
2: With sulfuric acid
T=-30 - 0°C; Nef Reaction; 21.25 h; Product distribution / selectivity;
参考文献
TIBOTEC PHARMACEUTICALS Ltd.
Patent: WO2005/95410 A1, 2005 ;
Location in patent: Page/Page column 41-42 ;
