1: With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; tri-isopropoxy-borane in tetrahydrofuran; hexane
T=-78 - -40°C; 4 h;
2: With hydrogenchloride in tetrahydrofuran; hexane; water
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/94822 A1, 2005 ;
Location in patent: Page/Page column 32 ;
WO 2005/094822 A1
