trifluoroacetic anhydride in dichloromethane T=0 - 20°C; 3 h;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '11342938', constants.ctx, '0')">lithium hydroxide</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a> <br />T=20&deg;C;&nbsp;15&nbsp;h;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 98 percent / H₂ / Pd(OH)2/C / methanol / 12 h / 20 &deg;C<br />2: 93 percent / Et₃N; 4-(dimethylamino)pyridine / CH₂Cl₂ / 1.75 h / 0 - 20 &deg;C<br />3: 91 percent / aq. LiOH / tetrahydrofuran / 15 h / 20 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 93 percent / Et₃N; 4-(dimethylamino)pyridine / CH₂Cl₂ / 1.75 h / 0 - 20 &deg;C<br />2: 91 percent / aq. LiOH / tetrahydrofuran / 15 h / 20 &deg;C<br /> <br /> &nbsp;