7-碘-2,3-二氢-异吲哚-1-酮合成路线 （共 2 条）
反应条件
1.1: N-iodo-succinimide / palladium diacetate / N,N-dimethyl-formamide / 17 h / 100 °C
2.1: diazomethyl-trimethyl-silane / dichloromethane; diethyl ether / 0.75 h / 0 °C / Inert atmosphere
3.1: N-bromosuccinmide / dibenzoyl peroxide / chlorobenzene / 18 h / 90 °C
3.2: 17 h
View Scheme
参考文献
CANCER THERAPEUTICS CRC PTY LIMITED; HOLMES, Ian, Peter; BERGMAN, Ylva; LUNNISS, Gillian Elizabeth; NIKAC, Marica; CHOI, Neil; HEMLEY, Catherine Fae; WALKER, Scott Raymond; FOITZIK, Richard Charles; GANAME, Danny; LESSENE, Romina
Patent: WO2012/110773 A1, 2012 ;
WO 2012/110773 A1
反应条件
1.1: diazomethyl-trimethyl-silane / dichloromethane; diethyl ether / 0.75 h / 0 °C / Inert atmosphere
2.1: N-bromosuccinmide / dibenzoyl peroxide / chlorobenzene / 18 h / 90 °C
2.2: 17 h
View Scheme
参考文献
CANCER THERAPEUTICS CRC PTY LIMITED; HOLMES, Ian, Peter; BERGMAN, Ylva; LUNNISS, Gillian Elizabeth; NIKAC, Marica; CHOI, Neil; HEMLEY, Catherine Fae; WALKER, Scott Raymond; FOITZIK, Richard Charles; GANAME, Danny; LESSENE, Romina
Patent: WO2012/110773 A1, 2012 ;
WO 2012/110773 A1
