3-硝基-5-三氟甲基-吡啶-2-甲腈合成路线 （共 8 条）
反应条件
1.1: hydrogen / palladium 10 on activated carbon / ethyl acetate / 18 h / Inert atmosphere 2.1: hydrogenchloride; water / 24 h / Reflux 3.1: sulfuric acid / 48 h / Reflux 3.2: 20 °C 4.1: sodium hydroxide; methanol / 0.02 h / 20 °C 4.2: pH 1 View Scheme
参考文献
NOVARTIS AG
Patent: US2011/230483 A1, 2011 ;
反应条件
tetrabutylammomium bromide in toluene
10 h; Reflux;
参考文献
NOVARTIS AG
Patent: US2011/230483 A1, 2011 ;
Location in patent: Page/Page column 32 ;
反应条件
in 1-methyl-pyrrolidin-2-one
T=175°C; 0.25 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/97805 A1, 2005 ;
Location in patent: Page/Page column 62 ;
反应条件
tetrabutylammomium bromide; copper (I) cyanide in toluene
9 h; Reflux;
参考文献
NOVARTIS AG; BALA, Kamlesh, Jagdis; BUTLER, Rebecca; COLLINGWOOD, Stephen, Paul; HALL, Edward, Charles; EDWARDS, Lee; LEGRAND, Darren, Mark; SPIEGEL, Katrin
Patent: WO2013/38386 A1, 2013 ;
Location in patent: Page/Page column 81 ;
反应条件
1: phosphorus oxytribromide / acetonitrile / 20 °C / Reflux
2: tetrabutylammomium bromide / toluene / 10 h / Reflux
View Scheme
参考文献
NOVARTIS AG
Patent: US2011/230483 A1, 2011 ;
反应条件
1: 3-nitro-5-trifluoromethyl-pyridine-2-carbonitrile With palladium 10 on activated carbon; hydrogen in ethyl acetate
18 h;
2: With hydrogenchloride; water
24 h; Reflux;
3: methanol With sulfuric acid
84 h; Reflux;
参考文献
NOVARTIS AG; LEGRAND, Darren Mark
Patent: WO2013/38378 A1, 2013 ;
Location in patent: Page/Page column 49 ;
反应条件
1.1: hydrogen / palladium 10 on activated carbon / ethyl acetate / 18 h / Inert atmosphere
2.1: hydrogenchloride; water / 24 h / Reflux
3.1: sulfuric acid / 48 h / Reflux
3.2: 20 °C
View Scheme
参考文献
NOVARTIS AG
Patent: US2011/230483 A1, 2011 ;
反应条件
1.1: hydrogen / palladium 10 on activated carbon / ethyl acetate / 18 h / Inert atmosphere
2.1: hydrogenchloride; water / 24 h / Reflux
3.1: sulfuric acid / 48 h / Reflux
3.2: 20 °C
4.1: bromine; sulfuric acid; acetic acid / water / 20 h / 20 °C
View Scheme
参考文献
NOVARTIS AG; LEGRAND, Darren Mark
Patent: WO2013/38378 A1, 2013 ;
