1: With methanol; sodium hydroxide T=20°C; 0.0166667 h; 2: With hydrogenchloride in methanol; water pH=1;

1: 3-nitro-5-trifluoromethyl-pyridine-2-carbonitrile With palladium 10 on activated carbon; hydrogen in ethyl acetate 18 h; 2: With hydrogenchloride; water 24 h; Reflux; 3: methanol With sulfuric acid 84 h; Reflux;

1: With sulfuric acid 48 h; Reflux; 2: With sodium hydrogencarbonate in methanol; water T=20°C;

1.1: phosphorus oxytribromide / acetonitrile / 20 °C / Reflux 2.1: tetrabutylammomium bromide / toluene / 10 h / Reflux 3.1: hydrogen / palladium 10 on activated carbon / ethyl acetate / 18 h / Inert atmosphere 4.1: hydrogenchloride; water / 24 h / Reflux 5.1: sulfuric acid / 48 h / Reflux 5.2: 20 °C View Scheme

1.1: tetrabutylammomium bromide / toluene / 10 h / Reflux 2.1: hydrogen / palladium 10 on activated carbon / ethyl acetate / 18 h / Inert atmosphere 3.1: hydrogenchloride; water / 24 h / Reflux 4.1: sulfuric acid / 48 h / Reflux 4.2: 20 °C View Scheme

1.1: hydrogen / palladium 10 on activated carbon / ethyl acetate / 18 h / Inert atmosphere 2.1: hydrogenchloride; water / 24 h / Reflux 3.1: sulfuric acid / 48 h / Reflux 3.2: 20 °C View Scheme

1: With sulfuric acid; bromine; acetic acid in water T=20°C; 20 h; 2: With sodium hydrogencarbonate in water