反应条件
1: ((R)-2-hydroxy-3-{3-[(1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carbonyl)amino]-(1S,3R,5R)-8-azabicyclo[3.2.1]oct-8-yl}propyl)methylcarbamic acid tert-butyl ester With trifluoroacetic acid in dichloromethane 2: methanesulfonyl chloride With 1,8-diazabicyclo[5.4.0]undec-7-ene in dichloromethane T=0°C;
参考文献
Long, Daniel D.; Armstrong, Scott R.; Beattie, David T.; Choi, Seok-Ki; Fatheree, Paul R.; Gendron, Roland A.L.; Genov, Daniel; Goldblum, Adam A.; Humphrey, Patrick P.; Jiang, Lan; Marquess, Daniel G.; Shaw, Jeng-Pyng; Smith, Jacqueline A.M.; Turner, S. Derek; Vickery, Ross G.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 19 p. 6048 - 6052