1: 1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid {(1S,3R,5R)-8-aza-bicyclo[3.2.1]oct-3-yl}amide trifluoroacetate With sodium hydroxide in ethanol; water T=20°C; 0.5 h; 2: N-methyl-N-[(S)-2-oxiran-2-ylmethyl]methanesulfonamide in ethanol; water 2 h; Heating / reflux;