(1S)-4,5-二甲氧基-1-[(甲基氨基)甲基]苯并环丁烷盐酸盐合成路线 （共 14 条）
反应条件
1: 3-[2-(1,3-dioxolan-2-yl)ethyl]-7,8-dimethoxy-1,3-dihydro-2H-3-benz-azepin-2-one With hydrogen; palladium on activated charcoal in ethanol T=55°C; P=3750.38 Torr; 2: 1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride in ethanol; water T=20 - 85°C; P=22502.3 Torr;
参考文献
Lerestif, Jean-Michel; Lecouve, Jean-Pierre; Souvie, Jean-Claude; Brigot, Daniel; Horvath, Stephane; Auguste, Marie-Noelle; Damien, Gerard
Patent: US2005/228177 A1, 2005 ;
Location in patent: Page/Page column 3-4 ;
反应条件
1.1: potassium carbonate; sodium iodide / 1-methyl-pyrrolidin-2-one / 20 - 60 °C / Inert atmosphere 1.2: 2 h / 20 °C 2.1: potassium carbonate / water / 0.08 h 2.2: Inert atmosphere 3.1: hydrogenchloride; hydrogen / palladium 10 on activated carbon / water / 6 h / 45 °C / 7500.75 Torr View Scheme
参考文献
RICHTER GEDEON NYRT.; UJVARI, Viktor; BODI, Jozsef; FARAGO, Janos; SZKE, Katalin; FAIGL, Ferenc; NEMET, Zoltan; TEMESVARI, Krisztina; KISS, Robert; MATRAVOeLGYI, Bela; KASSAI, Ferencne; KISS-BARTOS, Dorottya
Patent: WO2011/138625 A1, 2011 ;
反应条件
potassium carbonate in acetone
T=55 - 58°C; 3 h;
参考文献
BIOCON LIMITED; KOTHAKONDA, Kiran Kumar; RAMASAMY, Sivakumar; BANDARU, Sravan Kumar; VENKATA, Srinivas Pullela
Patent: WO2014/20534 A1, 2014 ;
Location in patent: Page/Page column 13; 14 ;
反应条件
1.1: potassium carbonate; sodium iodide / 1-methyl-pyrrolidin-2-one / 20 - 60 °C / Inert atmosphere
1.2: 2 h / 20 °C
2.1: potassium carbonate / water / 0.08 h
2.2: Inert atmosphere
View Scheme
参考文献
RICHTER GEDEON NYRT.; UJVARI, Viktor; BODI, Jozsef; FARAGO, Janos; SZKE, Katalin; FAIGL, Ferenc; NEMET, Zoltan; TEMESVARI, Krisztina; KISS, Robert; MATRAVOeLGYI, Bela; KASSAI, Ferencne; KISS-BARTOS, Dorottya
Patent: WO2011/138625 A1, 2011 ;
