1,5-二羟基-3,4-二甲氧基-10-甲基-9(10H)-吖啶酮合成路线 （共 13 条）
反应条件
1: 12 percent / CuCl, K2CO3 / 2-ethoxy-ethanol / 6 h / Heating
2: 59 percent / polyphosphoric acid (PPA) / 1 h / 115 °C
3: 66 percent / K2CO3 / propan-2-ol / 2 h / Heating
4: 78 percent / KOH / dimethylsulfoxide / 1 h / Ambient temperature
5: 20 percent / 6 N aq. HCl / ethanol / 4 h / Heating
View Scheme
参考文献
Kato; Fujita; Fujimura; Kawashima; Nishiyama
Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 3 p. 445 - 452
反应条件
1: 48 percent / 6 N aq. HCl / ethanol / 4 h / Heating
2: 95 percent / H2 / 5percent Pd/C / methanol; acetone / 1 h / 50 °C
View Scheme
参考文献
Kato; Fujita; Fujimura; Kawashima; Nishiyama
Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 3 p. 445 - 452
反应条件
hydrogenchloride in ethanol
4 h; Heating;
参考文献
Kato; Fujita; Fujimura; Kawashima; Nishiyama
Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 3 p. 445 - 452
