1: With sodium hydroxide; ethanol; water 30 h; Heating / reflux; 2: With hydrogenchloride; water in toluene pH=5.6; 0.5 h; Product distribution / selectivity;

1: 2-(1-((((R)-1-(3-((E)-2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)propyl)sulfanyl)methyl)cyclopropyl)acetonitrile With sodium hydroxide; water in toluene T=125°C; 15 h; 2: N,N-dicyclohexylamine in acetone T=25 - 35°C; 10 h; Product distribution / selectivity;

1: With sodium hydroxide; ethanol; water 15 h; Heating / reflux; 2: With acetic acid in ethanol; water; toluene Product distribution / selectivity;

1: With sodium hydroxide; ethanol; water 30 h; Heating / reflux; 2: With hydrogenchloride; water in toluene pH=5.6; 0.5 h; Product distribution / selectivity;

1: caustic lye / 12 h / 120 °C 2: sodium hydroxide / methanol / 1 h / 25 °C View Scheme