(R)-(+)-2-氨基-3-甲基-1,1-二苯基-1-丁醇合成路线 （共 6 条）
反应条件
chiral stationary phase including (R)-naphthylethyl-carbamate-functionalized CF6 in ethanol; n-heptane; trifluoroacetic acid T=20°C; Purification / work up;
参考文献
WO2010/148191 A2, ;
Page/Page column 45-49; 64 ;
反应条件
hydrogenchloride; methanol T=20°C;
参考文献
Vabeno, Jon; Brisander, Magnus; Lejon, Tore; Luthman, Kristina
Journal of Organic Chemistry, 2002 , vol. 67, # 26 p. 9186 - 9191
反应条件
in tetrahydrofuran T=0 - 10°C; 5 h;
参考文献
Itsuno, Shinichi; Nakano, Michio; Miyazaki, Koji; Masuda, Hirofumi; Ito, Koichi; et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 2039 - 2044
反应条件
1: 27 percent / diethyl ether / 4 h / 20 °C 2: 26 percent / MeOH; HCl / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 67, # 26 p. 9186 - 9191
反应条件
(i) EtOH, HCl, (ii) /BRN= 4720968/, Et2O; Multistep reaction;
参考文献
Helvetica Chimica Acta, , vol. 43, p. 1915 - 1927
反应条件
Title compound not separated from byproducts;
参考文献
Journal of the Chemical Society, Chemical Communications, , # 8 p. 469 - 470
