(4Z,8Z,12Z,16Z)-N,N-二乙基-4,8,13,17,21-五甲基-4,8,12,16,20-二十二碳五烯-1-胺合成路线 （共 3 条）
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86699-75-4(4Z,8Z,12Z,16Z)-N,N-二乙基-4,8,13,17,21-五甲基-4,8,12,16,20-二十二碳五烯-1-胺
反应条件
hydrogenchloride; sodium cyanoborohydride in tetrahydrofuran
0.5 h; Ambient temperaturepH 3;
参考文献
Ceruti, Maurizio; Balliano, Gianni; Viola, Franca; Cattel, Luigi; Gerst, Nicolas; Schuber, Francis
European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 199 - 208
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86699-75-4(4Z,8Z,12Z,16Z)-N,N-二乙基-4,8,13,17,21-五甲基-4,8,12,16,20-二十二碳五烯-1-胺
反应条件
1: NBS / tetrahydrofuran; H2O / 1.) 30 min, 0 deg C; 2.) 1 h, RT
2: K2CO3 / methanol / 2 h / Ambient temperature
3: 19.2 g / HIO4*2H2O / diethyl ether / 0.17 h
4: 46 percent / HCl, NaBH3CN / tetrahydrofuran / 0.5 h / Ambient temperature; pH 3
View Scheme
参考文献
Ceruti, Maurizio; Balliano, Gianni; Viola, Franca; Cattel, Luigi; Gerst, Nicolas; Schuber, Francis
European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 199 - 208
→
86699-75-4(4Z,8Z,12Z,16Z)-N,N-二乙基-4,8,13,17,21-五甲基-4,8,12,16,20-二十二碳五烯-1-胺
反应条件
1: 19.2 g / HIO4*2H2O / diethyl ether / 0.17 h
2: 46 percent / HCl, NaBH3CN / tetrahydrofuran / 0.5 h / Ambient temperature; pH 3
View Scheme
参考文献
Ceruti, Maurizio; Balliano, Gianni; Viola, Franca; Cattel, Luigi; Gerst, Nicolas; Schuber, Francis
European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 199 - 208
