1: diethoxyphosphoryl-acetic acid ethyl ester With sodium ethanolate in ethanol
T=20°C; 0.166667 h;
2: cyclohexyl ethyl ketone in ethanol
T=20°C; 15 h; Title compound not separated from byproducts;
参考文献
Ouellet, Stephane G.; Tuttle, Jamison B.; MacMillan, David W. C.
Journal of the American Chemical Society, 2005 , vol. 127, # 1 p. 32 - 33
McDonald, Ian A.; Lacoste, Jean Michel; Bey, Philippe; Wagner, Joseph; Zreika, Monique; Palfreyman, Michael G.
Journal of the American Chemical Society, 1984 , vol. 106, # 11 p. 3354 - 3356
1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride in tetrahydrofuran
Cooling with ice;
2: pivalaldehyde in tetrahydrofuran
T=20°C; 48 h;
3: With ammonium chloride in tetrahydrofuran; water
参考文献
Institute Of Medicinal Molecular Design, Inc.; ShionogiandCo., Ltd.
Patent: EP2208728 A1, 2010 ;
Location in patent: Page/Page column 172 ;