2-(3-呋喃羰基)-3-氧代-2,8-二氮杂螺[4.5]癸烷-8-羧酸 1,1-二甲基乙酯合成路线 (共 1 条)
反应条件
1: 3-oxo-2,8-diazaspirolt;4.5gt;decane-8-carboxylic acid tert-butyl ester With sodium hydride in tetrahydrofuran
T=5°C; 1 h;
2: furan-3-carboxylic acid chloride in tetrahydrofuran
T=0 - 20°C; 3 h;
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2005/97794 A1, 2005 ;
Location in patent: Page/Page column 41-42 ;
WO 2005/097794 A1