1.1: NaOEt / ethanol / 21 h / Heating 2.1: 3.16 g / K2CO3 / acetone / 20 h / Heating 3.1: LDA / tetrahydrofuran / 0.17 h / -70 °C 3.2: tetrahydrofuran / 1 h / -70 °C 4.1: TFA / 1 h / 20 °C 4.2: 0.798 mg / K2CO3 / acetone / 3.5 h / Heating 5.1: 100 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 0 °C 6.1: PBr3 / tetrahydrofuran / 1 h / -78 °C 6.2: 72 percent / LiAlH4 / tetrahydrofuran / 1.92 h 7.1: 49 percent / PBr3 / tetrahydrofuran / 1 h / 60 °C 8.1: 99 percent / n-Bu3SnH / toluene / 12 h / Heating View Scheme

1.1: 3.16 g / K2CO3 / acetone / 20 h / Heating 2.1: LDA / tetrahydrofuran / 0.17 h / -70 °C 2.2: tetrahydrofuran / 1 h / -70 °C 3.1: TFA / 1 h / 20 °C 3.2: 0.798 mg / K2CO3 / acetone / 3.5 h / Heating 4.1: 100 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 0 °C 5.1: PBr3 / tetrahydrofuran / 1 h / -78 °C 5.2: 72 percent / LiAlH4 / tetrahydrofuran / 1.92 h 6.1: 49 percent / PBr3 / tetrahydrofuran / 1 h / 60 °C 7.1: 99 percent / n-Bu3SnH / toluene / 12 h / Heating View Scheme

1.1: LDA / tetrahydrofuran / 0.17 h / -70 °C 1.2: tetrahydrofuran / 1 h / -70 °C 2.1: TFA / 1 h / 20 °C 2.2: 0.798 mg / K2CO3 / acetone / 3.5 h / Heating 3.1: 100 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 0 °C 4.1: PBr3 / tetrahydrofuran / 1 h / -78 °C 4.2: 72 percent / LiAlH4 / tetrahydrofuran / 1.92 h 5.1: 49 percent / PBr3 / tetrahydrofuran / 1 h / 60 °C 6.1: 99 percent / n-Bu3SnH / toluene / 12 h / Heating View Scheme

1.1: TFA / 1 h / 20 °C 1.2: 0.798 mg / K2CO3 / acetone / 3.5 h / Heating 2.1: 100 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 0 °C 3.1: PBr3 / tetrahydrofuran / 1 h / -78 °C 3.2: 72 percent / LiAlH4 / tetrahydrofuran / 1.92 h 4.1: 49 percent / PBr3 / tetrahydrofuran / 1 h / 60 °C 5.1: 99 percent / n-Bu3SnH / toluene / 12 h / Heating View Scheme