反应条件
1: With caesium carbonate; triphenylphosphine in water; N,N-dimethyl-formamide T=95 - 105°C; Industry scaleInert atmosphere; 2: With palladium diacetate in N,N-dimethyl-formamide Industry scaleInert atmosphere;
参考文献
OSI PHARMACEUTICALS, LLC; CASTELHANO, Arlindo, L.; CUTTING, Gary, A.; LOCKE, Andrew, J.; MAO, Yunyu; MULVIHILL, Kristen, Michelle; NORRIE, Robert; O'BRIEN, Andrew, J.; PARK, Stuart, R.; RECHKA, Josef, A.; STEVENS, Andrew, Michael; THOMAS, Christopher, I.
Patent: WO2012/16095 A1, 2012 ;
Location in patent: Page/Page column 12-13 ;