4-溴-7-氯-8-氟-2-苯基喹啉合成路线 （共 5 条）
反应条件
phosphoryl(III) bromide in acetonitrile
T=100°C;
参考文献
OSI PHARMACEUTICALS, INC.
Patent: WO2005/97800 A1, 2005 ;
Location in patent: Page/Page column 426 ;
WO 2005/097800 A1
反应条件
1: toluene-4-sulfonic acid / toluene / 3 h / Reflux; Dean-Stark apparatus
2: polyphosphoric acid / 0.67 h / 175 °C / Inert atmosphere
3: phosphorus oxytribromide / acetonitrile / 100 °C / Sealed tube
View Scheme
参考文献
OSI PHARMACEUTICALS, INC.; EPSTEIN, David, M.; JIN, Meizhong; MULVIHILL, Mark, J.
Patent: WO2011/60112 A1, 2011 ;
WO 2011/060112 A1
反应条件
1: toluene-4-sulfonic acid / toluene / 3 h / Reflux; Dean-Stark apparatus
2: polyphosphoric acid / 0.67 h / 175 °C / Inert atmosphere
3: phosphorus oxytribromide / acetonitrile / 100 °C / Sealed tube
View Scheme
参考文献
OSI PHARMACEUTICALS, INC.; EPSTEIN, David, M.; JIN, Meizhong; MULVIHILL, Mark, J.
Patent: WO2011/60112 A1, 2011 ;
WO 2011/060112 A1
反应条件
1: polyphosphoric acid / 0.67 h / 175 °C / Inert atmosphere
2: phosphorus oxytribromide / acetonitrile / 100 °C / Sealed tube
View Scheme
参考文献
OSI PHARMACEUTICALS, INC.; EPSTEIN, David, M.; JIN, Meizhong; MULVIHILL, Mark, J.
Patent: WO2011/60112 A1, 2011 ;
WO 2011/060112 A1
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane
T=-100 - -90°C; 0.1 h;
2: With acetic acid
0.333333 h; Product distribution / selectivity;
参考文献
OSI PHARMACEUTICALS, INC.
Patent: WO2005/97800 A1, 2005 ;
Location in patent: Page/Page column 423-424 ;
WO 2005/097800 A1
