2-[[(2-碘苯基)甲基]硫]乙酸合成路线 （共 4 条）
反应条件
1: 1-(bromomethyl)-2-iodobenzene With thiourea in water
T=60°C; 0.5 h; Heating / reflux;
2: With sodium hydroxide in water
T=60°C; 0.0833333 h; Heating / reflux;
3: sodium salt of the chloroacetic acid in water
T=110°C; 1 h;
参考文献
CEPHALON, INC.; CEPHALON FRANCE
Patent: EP1586559 A1, 2005 ;
Location in patent: Page/Page column 22 ;
反应条件
1: 2-(2-iodo-benzyl)-isothiourea With sodium hydroxide
T=80°C; 1 h;
2: chloroacetic acid 2 h; Reflux;
参考文献
Lesur, Brigitte; Lin, Yin G.; Marcy, Val R.; Aimone, Lisa D.; Gruner, John; Bacon, Edward R.; Chatterjee, Sankar
Chemical Biology and Drug Design, 2013 , vol. 81, # 3 p. 429 - 432
反应条件
1: hydrogen bromide / water / 0.5 h / 60 °C / Reflux
2: sodium hydroxide / 1 h / 80 °C
3: 2 h / Reflux
View Scheme
参考文献
Dunn, Derek; Hostetler, Greg; Iqbal, Mohamed; Messina-Mclaughlin, Patricia; Reiboldt, Alyssa; Lin, Yin Guo; Gruner, John; Bacon, Edward R.; Ator, Mark A.; Chatterjee, Sankar
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 6 p. 2315 - 2317
参考文献
Dunn, Derek; Hostetler, Greg; Iqbal, Mohamed; Messina-Mclaughlin, Patricia; Reiboldt, Alyssa; Lin, Yin Guo; Gruner, John; Bacon, Edward R.; Ator, Mark A.; Chatterjee, Sankar
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 6 p. 2315 - 2317
