(S)-4-氯-3-羟基丁酸甲酯合成路线 （共 16 条）
反应条件
sodium azide; alcohol dehydrogenase from Lactobacillus brevis; halohydrin dehalogenase from Mycobacterium sp. GP1; NADPH; isopropyl alcohol T=30°C; pH=7.5; 24 h; aq. bufferEnzymatic reaction; optical yield given as percent ee;
参考文献
European Journal of Organic Chemistry, , # 14 p. 2293 - 2298
反应条件
Tris-HCl buffer T=30°C; pH=7.5; 24 h; Enzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of Organic Chemistry, , vol. 74, # 4 p. 1730 - 1732
反应条件
1: 1-chloro-3-phenoxy-2-propanone With alcohol dehydrogenase from Lactobacillus brevis; NADPH; isopropyl alcohol T=30°C; pH=7.5; 6 h; aq. bufferEnzymatic reaction; 2: sodium cyanide With halohydrin dehalogenase from Mycobacterium sp. GP1 T=30°C; pH=7.5; 18 h; aq. bufferEnzymatic reaction; optical yield given as percent ee;
参考文献
European Journal of Organic Chemistry, , # 14 p. 2293 - 2298
反应条件
1: With Lactobacillus brevis alcohol dehydrogenase; isopropyl alcohol T=30°C; 4 h; aq. bufferEnzymatic reaction; 2: With Mycobacterium sp. GP1 halohydrin dehalogenase HheB T=30°C; 20 h; aq. bufferEnzymatic reaction; optical yield given as percent eestereoselective reaction;
参考文献
Tetrahedron Asymmetry, , vol. 20, # 4 p. 483 - 488
反应条件
halohydrin dehalogenase Trp249Phe mutant; Tris-SO4 buffer in dimethyl sulfoxide T=22°C; pH=7.5; 1.5 h; Product distribution; Further Variations:Reagentsreaction times;
参考文献
Organic Letters, , vol. 8, # 19 p. 4227 - 4229
反应条件
1: With sodium tetrahydroborate in methanol; toluene T=20°C; 13 h; 2: With hydrogenchloride; water in methanol; toluene T=10°C; Product distribution / selectivity;
参考文献
RSTECH CORPORATION
Patent: WO2008/93955 A1, 2008 ;
Location in patent: Paragraph 89-90 ;
