3-苄基-3,7-二氮杂双环[3.3.0]辛烷合成路线 （共 11 条）
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 5 h; Heating / reflux; 2: With water; sodium sulfate in tetrahydrofuran T=0 - 20°C; 16 h;
参考文献
TARGACEPT, INC.
Patent: WO2008/57938 A1, 2008 ;
Location in patent: Page/Page column 30 ;
WO 2008/057938 A1
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran 5 h; Heating / reflux; 2: With potassium hydroxide in water
参考文献
BAYER AKTIENGESELLSCHAFT
Patent: WO2003/106450 A1, 2003 ;
Location in patent: Page column 53 ;
WO 03/106450 A1
反应条件
1: 1-benzyl-1H-pyrrole-2,5-dione; N-benzylglycine hydrochloride With paraformaldehyde; triethylamine in benzene 3.5 h; Heating / reflux; 2: 1-chloroethyl chlorocarbonate in 1,2-dichloro-ethane Heating / reflux; 3: With lithium aluminium tetrahydride in tetrahydrofuran
参考文献
US6355641 B1, ;
Page column 39 ;
US 6355641 B1
反应条件
1: 88 percent / dicyclohexylcarbodiimide / tetrahydrofuran / Heating; overnight 2: 84 percent / tetrahydrofuran / 60 °C / overnight 3: 90 percent / SOCl2 / dimethylformamide / 0.75 h / 45 °C 4: H2 / 10percent Pd/C / acetic acid / 18 h / 55 °C / 2585.7 Torr 5: 78 percent / LiAlH4 / tetrahydrofuran; diethyl ether / 16 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 20, p. 321 - 329
反应条件
1: 84 percent / tetrahydrofuran / 60 °C / overnight 2: 90 percent / SOCl2 / dimethylformamide / 0.75 h / 45 °C 3: H2 / 10percent Pd/C / acetic acid / 18 h / 55 °C / 2585.7 Torr 4: 78 percent / LiAlH4 / tetrahydrofuran; diethyl ether / 16 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 20, p. 321 - 329
反应条件
1: H2 / 10percent Pd/C / acetic acid / 18 h / 55 °C / 2585.7 Torr 2: 78 percent / LiAlH4 / tetrahydrofuran; diethyl ether / 16 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 20, p. 321 - 329
反应条件
1: 90 percent / SOCl2 / dimethylformamide / 0.75 h / 45 °C 2: H2 / 10percent Pd/C / acetic acid / 18 h / 55 °C / 2585.7 Torr 3: 78 percent / LiAlH4 / tetrahydrofuran; diethyl ether / 16 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 20, p. 321 - 329
反应条件
1: trifluoroacetic acid / dichloromethane / 6 h / -5 - 20 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / -5 °C / |Reflux View Scheme
反应条件
in tetrahydrofuran T=20°C; 18 h;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2005/121145 A2, 2005 ;
Location in patent: Page/Page column 150-151 ;
WO 2005/121145 A2
反应条件
1: dichloromethane / 24 h / 23 °C 2: hydrogen / palladium 10 on activated carbon / acetic acid; methanol / 72 h / 3620.13 Torr View Scheme
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Jiancun; ZHANG, Yingjun; ZHANG, Weihong; LIU, Bing; ZHANG, Jiquan; LIU, Jinlei; ZHANG, Lu
Patent: WO2013/71697 A1, 2013 ;
