2-苯基-八氢-吡咯并[3,4-c]吡咯合成路线 （共 5 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran; diethyl ether
Heating;
参考文献
Ohnmacht, Cyrus J.; Draper, Clyde W.; Dedinas, Robert F.; Loftus, Philip; Wong, J. J.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 321 - 329
反应条件
1: 88 percent / dicyclohexylcarbodiimide / tetrahydrofuran / Heating; overnight
2: 86 percent / acetonitrile
3: 1.) SOCl2 / 1.) benzene, reflux, 1.5 h; 2.) hexamethylphosphoramide, 180 deg C
4: H2 / 10percent Pd/C / acetic acid / 18 h / 55 °C / 2585.7 Torr
5: 60 percent / LiAlH4 / tetrahydrofuran; diethyl ether / Heating
View Scheme
参考文献
Ohnmacht, Cyrus J.; Draper, Clyde W.; Dedinas, Robert F.; Loftus, Philip; Wong, J. J.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 321 - 329
反应条件
1: 86 percent / acetonitrile
2: 1.) SOCl2 / 1.) benzene, reflux, 1.5 h; 2.) hexamethylphosphoramide, 180 deg C
3: H2 / 10percent Pd/C / acetic acid / 18 h / 55 °C / 2585.7 Torr
4: 60 percent / LiAlH4 / tetrahydrofuran; diethyl ether / Heating
View Scheme
参考文献
Ohnmacht, Cyrus J.; Draper, Clyde W.; Dedinas, Robert F.; Loftus, Philip; Wong, J. J.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 321 - 329
反应条件
1: H2 / 10percent Pd/C / acetic acid / 18 h / 55 °C / 2585.7 Torr
2: 60 percent / LiAlH4 / tetrahydrofuran; diethyl ether / Heating
View Scheme
参考文献
Ohnmacht, Cyrus J.; Draper, Clyde W.; Dedinas, Robert F.; Loftus, Philip; Wong, J. J.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 321 - 329
反应条件
1: 1.) SOCl2 / 1.) benzene, reflux, 1.5 h; 2.) hexamethylphosphoramide, 180 deg C
2: H2 / 10percent Pd/C / acetic acid / 18 h / 55 °C / 2585.7 Torr
3: 60 percent / LiAlH4 / tetrahydrofuran; diethyl ether / Heating
View Scheme
参考文献
Ohnmacht, Cyrus J.; Draper, Clyde W.; Dedinas, Robert F.; Loftus, Philip; Wong, J. J.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 321 - 329
