4-(4-溴-苯甲酰基)-哌嗪-1-羧酸叔丁酯合成路线 （共 4 条）
反应条件
triethylamine in dichloromethane
T=20°C; 15 h;
参考文献
TARGEGEN, INC.
Patent: WO2006/101977 A2, 2006 ;
Location in patent: Page/Page column 104 ;
WO 2006/101977 A2
反应条件
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine in dichloromethane
T=20°C; 18 h;
参考文献
SCHERING CORPORATION; DE LERA RUIZ, Manuel; BERLIN, Michael, Y.; ZHENG, Junying; ASLANIAN, Robert, G.; MCCORMICK, Kevin, D.; ZENG, Qingbei
Patent: WO2010/11653 A1, 2010 ;
Location in patent: Page/Page column 58 ;
WO 2010/011653 A1
反应条件
1: piperazine-1-carboxylic acid tert-butyl ester With sodium hydroxide in water
0.0833333 h;
2: 4-bromo-benzoyl chloride in tetrahydrofuran; water
0.0833333 h;
参考文献
BIOVITRUM AB (PUBL)
Patent: WO2007/147874 A1, 2007 ;
Location in patent: Page/Page column 131 ;
WO 2007/147874 A1
反应条件
1: With trifluoroacetic acid in dichloromethane
T=0 - 20°C; 4 h;
2: With sodium hydrogencarbonate in water; ethyl acetate
参考文献
Schering Corporation
Patent: US2007/167435 A1, 2007 ;
Location in patent: Page/Page column 61 ;
US 20070167435 A1
