1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran T=20°C; 12 h; Product distribution; Further Variations:Reagents;

1: diethoxyphosphoryl-acetic acid ethyl ester With n-butyllithium in tetrahydrofuran T=0 - 20°C; 2: N-(1-hydroxy-1-benzyl)pyrrole With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride in tetrahydrofuran; acetonitrile T=20°C; Wadsworth-Horner-Emmons olefination;

1: 99 percent / imidazole / dimethylformamide / 35 °C 2: 77 percent / TBAF / tetrahydrofuran / -78 - 20 °C View Scheme