1: 86 percent / aq. NH3 / tetrahydrofuran / 4 h 2: 50 percent / LiAlH4 / tetrahydrofuran / 6 h / Heating 3: 88 percent / pyridine / 0 °C 4: Br2 / CH2Cl2 / 2 h 5: KOH / ethanol / 20 h / Heating 6: 50 percent / Et3N / CH2Cl2 / 24 h / Ambient temperature 7: 1.) O3, 2.) Me2S / 1) CH2Cl2, MeOH, -78 deg C; 2) CH2Cl2, MeOH, 4 h 8: 80 percent / immobilized penicillin acylase / ethanol / 0.5 h / 23 °C / pH 7.5 View Scheme

carbon disulfide; aluminium trichloride

in dichloromethane

1.1: CH2Cl2 2.1: BuLi / diethyl ether / 0.5 h / 0 °C 2.2: 45 percent / NCS / diethyl ether / 2 h / 0 °C View Scheme

1: 20 percent / sodium carbonate / diethyl ether; H2O / 9 h 2: 96 percent / triethylamine / CCl4 / 2 h 3: thermolysis View Scheme