4-氟-3,5-二甲基苯甲腈合成路线 （共 4 条）
反应条件
[Pd(η3-1-Ph-allyl)(μ-Cl)]2; t-Bu Brett Phos; cesium fluoride in toluene
T=120°C; 0.333333 h; Inert atmosphere;
参考文献
Noel, Timothy; Maimone, Thomas J.; Buchwald, Stephen L.
Angewandte Chemie - International Edition, 2011 , vol. 50, # 38 p. 8900 - 8903
反应条件
Cu(NO3)2*3H2O; cesium fluoride in methanol; water
T=100°C; 3 h;
参考文献
Liskey, Carl W.; Liao, Xuebin; Hartwig, John F.
Journal of the American Chemical Society, 2010 , vol. 132, # 33 p. 11389 - 11391
反应条件
1: cesium fluoride / toluene / 24 h / 50 °C
2: tris-(dibenzylideneacetone)dipalladium(0); t-Bu Brett Phos; cesium fluoride / toluene / 0.5 h / 180 °C / |Microwave irradiation
View Scheme
参考文献
Wannberg, Johan; Wallinder, Charlotta; Uenluesoy, Meltem; Skoeld, Christian; Larhed, Mats
Journal of Organic Chemistry, 2013 , vol. 78, # 8 p. 4184 - 4189
反应条件
1: cesium fluoride / toluene; 1,4-dioxane / 72 h / 50 °C
2: tris-(dibenzylideneacetone)dipalladium(0); t-Bu Brett Phos; cesium fluoride / toluene / 0.5 h / 180 °C / |Microwave irradiation
View Scheme
参考文献
Wannberg, Johan; Wallinder, Charlotta; Uenluesoy, Meltem; Skoeld, Christian; Larhed, Mats
Journal of Organic Chemistry, 2013 , vol. 78, # 8 p. 4184 - 4189
