2-(2-溴-5-甲氧基苯基)乙酸合成路线 （共 10 条）
反应条件
1: 90 percent / conc. H2SO4 / 17 h / Heating 2: 55 percent / 10 h / 150 - 155 °C 3: POCl3 / acetonitrile / 4 h / Heating 4: NaBH4 / methanol; H2O / 2 h / Ambient temperature 5: sodium methylsulfinylmethanide / dimethylsulfoxide / 15 h View Scheme
参考文献
Ambros; Von Angerer; Wiegrebe
Archiv der Pharmazie, 1988 , vol. 321, # 8 p. 481 - 486
反应条件
sulfuric acid 0.5 h; Reflux;
参考文献
Kapadia, Nirav; Harding, Wayne
Tetrahedron, 2013 , vol. 69, # 42 p. 8914 - 8920
反应条件
bromine in dichloromethane
T=20°C; 24 h;
参考文献
Quin, Caroline; Trnka, Jan; Hay, Alison; Murphy, Michael P.; Hartley, Richard C.
Tetrahedron, 2009 , vol. 65, # 39 p. 8154 - 8160
反应条件
1: With water; sodium hydroxide in ethanol
18 h; Reflux;
2: With hydrogenchloride in ethanol
pH=2;
参考文献
Kukosha, Tatyana; Trufilkina, Nadezhda; Katkevics, Martins
Synlett, 2011 , # 17 p. 2525 - 2528
反应条件
1: 69 percent / Br2, (PhCO2)2 / CCl4 / 1 h / Heating
2: dimethylsulfoxide / 0.75 h / Ambient temperature
3: aq. KOH / ethanol / 14 h / Heating
View Scheme
参考文献
Ghosh, Ajit K.; Mukhopadhyaya, Jayanta K.; Ghatak, Usha Ranjan
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 18 p. 2747 - 2755
反应条件
1: dimethylsulfoxide / 0.75 h / Ambient temperature
2: aq. KOH / ethanol / 14 h / Heating
View Scheme
参考文献
Ghosh, Ajit K.; Mukhopadhyaya, Jayanta K.; Ghatak, Usha Ranjan
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 18 p. 2747 - 2755
参考文献
Pschorr
Justus Liebigs Annalen der Chemie, 1912 , vol. 391, p. 44
参考文献
Amupitan,J.O.; Stansfield,F.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1974 , p. 1949 - 1951
参考文献
Pschorr
Justus Liebigs Annalen der Chemie, 1912 , vol. 391, p. 44
反应条件
1: conc. H2SO4 / 7 h / Heating
2: 93 percent / LiAlH4 / diethyl ether / 2 h / 25 - 30 °C
View Scheme
参考文献
Kapadia, Nirav; Harding, Wayne
Tetrahedron, 2013 , vol. 69, # 42 p. 8914 - 8920
