2-溴-1-(4-氟-1H-吡咯并[2,3-B]吡啶-3-基)-乙酮合成路线 (共 2 条)
反应条件
1: 4-fluoro-1H-pyrrolo[2,3-b]pyridine With AlCl3, aluminium chloride in dichloromethane
T=20°C; 0.5 h;
2: 2-bromo acetyl bromide in dichloromethane
T=50°C; 1 h;
3: With water in dichloromethane
T=100°C;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2005/103050 A2, 2005 ;
Location in patent: Page/Page column 179 ;
WO 2005/103050 A2
反应条件
1: in ethanol
T=70°C; 1 h;
2: With sodium carbonate in water
pH=~ 7.5;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2005/103050 A2, 2005 ;
Location in patent: Page/Page column 179-180 ;
WO 2005/103050 A2