5-氟-1-三异丙基甲硅烷基-1H-吡咯并[2,3-b]吡啶合成路线 （共 2 条）
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran T=20°C; 0.25 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2005/103050 A2, 2005 ;
Location in patent: Page/Page column 180-181 ;
WO 2005/103050 A2
反应条件
1: With n-butyllithium in tetrahydrofuran
T=-78°C; 1.16667 h;
2: With N-fluoro-N-(phenylsulfonyl)benzene-sulfonamide in tetrahydrofuran
T=-78°C; 2 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2005/103050 A2, 2005 ;
Location in patent: Page/Page column 180-189 ;
WO 2005/103050 A2
