(4-溴噻吩-2-基)氨基甲酸叔丁酯合成路线 （共 4 条）
反应条件
diphenyl phosphoryl azide; triethylamine T=85°C; 15 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2007/76423 A2, 2007 ;
Location in patent: Page/Page column 65 ;
WO 2007/076423 A2
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; water
T=170°C; 0.166667 h; Microwave heating;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2005/103050 A2, 2005 ;
Location in patent: Page/Page column 183-184 ;
WO 2005/103050 A2
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane; water
T=70°C; Suzuki Coupling; 4 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2007/76423 A2, 2007 ;
Location in patent: Page/Page column 66 ;
WO 2007/076423 A2
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane; water
T=70°C; Suzuki Coupling; 4 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2007/76423 A2, 2007 ;
Location in patent: Page/Page column 84-85 ;
WO 2007/076423 A2
