N-(3-甲基-2-吡啶)-2,2-二甲基丙酰胺合成路线 （共 10 条）
反应条件
1: 1.) n-BuLi / 1.) THF 2: 3N HCl / Heating 3: p-TsOH / pentan-1-ol / Heating View Scheme
参考文献
Cheng, Xinlai; Merz, Karl-Heinz; Vatter, Sandra; Christ, Jochen; Woelfl, Stefan; Eisenbrand, Gerhard
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 247 - 255
反应条件
1.1: n-butyllithium / hexane; tetrahydrofuran / 4 h / -78 - -20 °C 1.2: -78 - 20 °C 2.1: hydrogenchloride / |Reflux 3.1: N-bromosuccinmide; dimethyl sulfoxide / 0.5 h / 120 °C View Scheme
参考文献
Cheng, Xinlai; Merz, Karl-Heinz; Vatter, Sandra; Christ, Jochen; Woelfl, Stefan; Eisenbrand, Gerhard
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 247 - 255
反应条件
n-butyllithium THF, 1) 0 degC, 4h, 2) 4h, room temp.; Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 48, # 20 p. 3401 - 3408
反应条件
hydrogenchloride in tetrahydrofuran; diethyl ether; water
参考文献
Schering Corporation
Patent: US5023265 A1, 1991 ;
反应条件
1: 1.) n-BuLi / 1.) THF 2: 3N HCl / Heating View Scheme
参考文献
Cheng, Xinlai; Merz, Karl-Heinz; Vatter, Sandra; Christ, Jochen; Woelfl, Stefan; Eisenbrand, Gerhard
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 247 - 255
反应条件
triethylamine in tetrahydrofuran; hexane; acetone
参考文献
Merck, Sharp and Dohme Ltd.
Patent: US5681959 A1, 1997 ;
反应条件
n-butyllithium
THF, hexane, 1) 0 degC, 4h, 2) -78 deg C to room temp.; Yield given. Multistep reaction;
参考文献
Turner, James A.
Journal of Organic Chemistry, 1983 , vol. 48, # 20 p. 3401 - 3408
反应条件
1: 79 percent / triethylamine / CH2Cl2 / 2 h / Ambient temperature
2: n-BuLi / THF, hexane, 1) 0 degC, 4h, 2) -78 deg C to room temp.
View Scheme
参考文献
Turner, James A.
Journal of Organic Chemistry, 1983 , vol. 48, # 20 p. 3401 - 3408
反应条件
1: 79 percent / triethylamine / CH2Cl2 / 2 h / Ambient temperature
2: n-BuLi / THF, hexane, 1) 0 degC, 4h, 2) -78 deg C to room temp.
View Scheme
参考文献
Turner, James A.
Journal of Organic Chemistry, 1983 , vol. 48, # 20 p. 3401 - 3408
反应条件
1: With tert.-butyl lithium in diethyl ether; pentane
T=-78 - -30°C; 5 h; Inert atmosphere;
2: With N,N-dimethyl-formamide in diethyl ether; pentane
T=-30°C; 0.166667 h; Inert atmosphere;
参考文献
Van Zandt, Michael C.; Doan, Brian; Sawicki, Diane R.; Sredy, Janet; Podjarny, Alberto D.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 7 p. 2006 - 2008
