1: in tetrahydrofuran T=4°C; 2 h; Heating / reflux; 2: With water; citric acid in tetrahydrofuran

1: 1-(1,3-dioxan-2-yl)-2-bromoethane With iodine; magnesium in tetrahydrofuran T=65°C; 2: benzyl {4-[methoxy(methyl)amino]-4-oxobutyl}methylcarbamate in tetrahydrofuran T=4 - 65°C; 2 h;

1.1: potassium hydroxide / water; toluene / 2 h 2.1: 1,1'-carbonyldiimidazole / dichloromethane / 1 h 2.2: 16 h 3.1: iodine; magnesium / tetrahydrofuran / 65 °C 3.2: 2 h / 4 - 65 °C View Scheme

hydrogen; 5-palladium/activated carbon in methanol T=50°C; P=3105.31 Torr; 16 h;