1: With water; potassium carbonate 2 h; Heating / reflux; 2: With hydrogenchloride in water T=20°C; pH=2; 5 h; Heating / reflux; 3: With sodium hydroxide in water pH=10 - 11;

1: ethyl (S)-3-[2-(1,3-dioxoisoindolin-2-yl)ethyl]-5-[(2-oxooxazolidin-4-yl)methyl]-1H-indole-2-carboxylate With methylamine in methanol T=20 - 30°C; Ing-Manske reaction; 4.5 h; 2: methanol; formaldehyd With sodium cyanoborohydride; acetic acid in water T=0 - 5°C; Esweiler-Clark methylation; pH=6.5 - 7; 3: With potassium carbonate in methanol; water T=0 - 5°C;