2-(三甲基硅烷基)苯甲腈合成路线 （共 7 条）
反应条件
2,2,6,6-tetramethylpiperidinyl-lithium in tetrahydrofuran
T=0°C; 0.25 h;
参考文献
Krizan, Timothy D.; Martin, J. C.
Journal of the American Chemical Society, 1983 , vol. 105, # 19 p. 6155 - 6157
反应条件
1: With pyridine; trifluoromethylsulfonic anhydride in dichloromethane
T=-40 - 0°C; 7 h;
2: With ethanol in dichloromethane
T=20°C; 18 h; Further stages.;
参考文献
Metallinos, Costa; Nerdinger, Sven; Snieckus, Victor
Organic Letters, 1999 , vol. 1, # 8 p. 1183 - 1186
反应条件
1: 2-cyanophenyl bromide With n-butyllithium in tetrahydrofuran; hexane
T=20°C;
2: chloro-trimethyl-silane in tetrahydrofuran; hexane
T=20°C;
参考文献
Nagaki, Aiichiro; Kim, Heejin; Usutani, Hirotsugu; Matsuo, Chika; Yoshida, Jun-Ichi
Organic and Biomolecular Chemistry, 2010 , vol. 8, # 5 p. 1212 - 1217
反应条件
1.1: s-BuLi; TMEDA / tetrahydrofuran / 2 h / -78 °C
1.2: 94 percent / tetrahydrofuran / 1 h / -78 °C
2.1: triflic anhydride; pyridine / CH2Cl2 / 7 h / -40 - 0 °C
2.2: 51 percent / ethanol / CH2Cl2 / 18 h / 20 °C
View Scheme
参考文献
Metallinos, Costa; Nerdinger, Sven; Snieckus, Victor
Organic Letters, 1999 , vol. 1, # 8 p. 1183 - 1186
反应条件
1.1: s-BuLi; TMEDA / tetrahydrofuran / 2 h / -78 °C
1.2: 94 percent / tetrahydrofuran / 1 h / -78 °C
2.1: triflic anhydride; pyridine / CH2Cl2 / 7 h / -40 - 0 °C
2.2: 51 percent / ethanol / CH2Cl2 / 18 h / 20 °C
View Scheme
参考文献
Metallinos, Costa; Nerdinger, Sven; Snieckus, Victor
Organic Letters, 1999 , vol. 1, # 8 p. 1183 - 1186
反应条件
in acetonitrile
5 h; Irradiation;
参考文献
Kyushin, Soichiro; Ehara, Yasushi; Nakadaira, Yasuhiro; Ohashi, Mamoru
Journal of the Chemical Society, Chemical Communications, 1989 , # 5 p. 279 - 280
参考文献
Kyushin, Soichiro; Ehara, Yasushi; Nakadaira, Yasuhiro; Ohashi, Mamoru
Journal of the Chemical Society, Chemical Communications, 1989 , # 5 p. 279 - 280
