ammonium acetate in acetic acid T=130°C; 3 h;

1: para-bromobenzonitrile; 3-hydroxy-3-phenyl-prop-1-yne With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine Sonogashira coupling; 16 h; Heating; 2: benzaldehyde With N-methyl-4-methyl-5-(2-hydroxyethyl)thiazolin iodide in triethylamine Stetter reaction; 8 h; Heating; 3: With 2-amino-acetamide in acetic acid; triethylamine Paal-Knorr reaction; 120 h; Heating; Further stages.;

1: Et3N; CuI / (Ph3P)2PdCl2 / 14 h / Heating 2: 285 mg / Et3N; 3,4-dimethyl-5-(2-hydroxyethyl)thiazolium iodide / tetrahydrofuran / 24 h / Heating 3: 224 mg / aq. NH4Cl; AcOH / 30 h / Heating View Scheme

1: 1.) n-butyllithium, 2.) cuprous iodide / THF, -75 gradC 2: 84 percent / cupric chloride, cupric oxide / acetone; H2O 3: 78 percent / ammonium acetate / acetic acid / 3 h / 130 °C View Scheme

1: 1.) n-butyllithium, 2.) cuprous iodide / THF, -75 gradC 2: 84 percent / cupric chloride, cupric oxide / acetone; H2O 3: 78 percent / ammonium acetate / acetic acid / 3 h / 130 °C View Scheme

1: 84 percent / cupric chloride, cupric oxide / acetone; H2O 2: 78 percent / ammonium acetate / acetic acid / 3 h / 130 °C View Scheme

1: 285 mg / Et3N; 3,4-dimethyl-5-(2-hydroxyethyl)thiazolium iodide / tetrahydrofuran / 24 h / Heating 2: 224 mg / aq. NH4Cl; AcOH / 30 h / Heating View Scheme

1: 285 mg / Et3N; 3,4-dimethyl-5-(2-hydroxyethyl)thiazolium iodide / tetrahydrofuran / 24 h / Heating 2: 224 mg / aq. NH4Cl; AcOH / 30 h / Heating View Scheme