(2E)-4-[4-(二甲基氨基)苯基]-4-氧代-2-丁烯酸合成路线 （共 4 条）
反应条件
1.1: anhydrous aluminum chloride / 1,1,2,2-tetrachloro-ethane / 0 °C
1.2: 91 percent / 1,1,2,2-tetrachloro-ethane / 0 - 20 °C
2.1: 33 percent / Li; HMPA / benzene / 24 h / 20 °C
3.1: tetramethylammonium hydroxide / methanol / 0 - 20 °C
4.1: p-toluenesulfonic acid / benzene / 4 h / Heating
View Scheme
参考文献
Chen, Heru; Zhong, Xianbin; Wei, Jin
Molecules, 2007 , vol. 12, # 5 p. 1170 - 1182
反应条件
1: tetramethylammonium hydroxide / methanol / 0 - 20 °C
2: p-toluenesulfonic acid / benzene / 4 h / Heating
View Scheme
参考文献
Chen, Heru; Zhong, Xianbin; Wei, Jin
Molecules, 2007 , vol. 12, # 5 p. 1170 - 1182
反应条件
1: 33 percent / Li; HMPA / benzene / 24 h / 20 °C
2: tetramethylammonium hydroxide / methanol / 0 - 20 °C
3: p-toluenesulfonic acid / benzene / 4 h / Heating
View Scheme
参考文献
Chen, Heru; Zhong, Xianbin; Wei, Jin
Molecules, 2007 , vol. 12, # 5 p. 1170 - 1182
反应条件
sodium hydroxide; sodium periodate; sulfuric acid
1) H2O, -5 to 0 deg C, 2) 50percent aq. EtOH, RT, 5 h then 60 deg C, 20 min; Yield given. Multistep reaction;
参考文献
Bianchi, Mario; Butti, Alina; Christidis, Yani; Perronnet, Jacques; Barzaghi, Fernando; et al.
European Journal of Medicinal Chemistry, 1988 , vol. 23, p. 45 - 52
