(2S)-2,4-吗啉二羧酸 4-叔丁酯合成路线 (共 4 条)
反应条件
2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; tetrabutyl-ammonium chloride; potassium bromide
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 20 p. 5550 - 5553
反应条件
1-methyl-1,4-cyclo-hexadiene; 10 Pd on charcoal in ethanol Reflux;
参考文献
Fish, Paul V.; Mackenny, Malcolm; Bish, Gerwyn; Buxton, Timothy; Cave, Russell; Drouard, David; Hoople, David; Jessiman, Alan; Miller, Duncan; Pasquinet, Christelle; Patel, Bhairavi; Reeves, Keith; Ryckmans, Thomas; Skerten, Melanie; Wakenhut, Florian
Tetrahedron Letters, 2009 , vol. 50, # 4 p. 389 - 391
反应条件
1: diborane / tetrahydrofuran / 2.5 h / |Reflux 2: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / 1,2-dichloro-ethane / 18 h / 70 °C View Scheme
参考文献
Proximagen Limited; Savory, Edward Daniel; Stewart, Allson; Cartey, Allison; Brown, Giles; Simpson, Iain; Oliver, Kathryn; Patient, Lee; Higginbottom, Michael; Cole, Andrew Graham
Patent: US2013/289020 A1, 2013 ;
反应条件
diborane in tetrahydrofuran 2.5 h; Reflux;
参考文献
Proximagen Limited; Savory, Edward Daniel; Stewart, Allson; Cartey, Allison; Brown, Giles; Simpson, Iain; Oliver, Kathryn; Patient, Lee; Higginbottom, Michael; Cole, Andrew Graham
Patent: US2013/289020 A1, 2013 ;
Location in patent: Paragraph 0368; 0369 ;