N-(4-氰基-2-碘-5-(三氟甲基)苯基)甲烷磺酰胺合成路线 （共 4 条）
反应条件
1: 4-amino-5-iodo-2-trifluoromethyl-benzonitrile With potassium tert-butylate in tetrahydrofuran
0.333333 h;
2: methanesulfonyl chloride in tetrahydrofuran
T=20°C;
3: With hydrogenchloride in tetrahydrofuran; water
参考文献
Lanter, James C.; Sui, Zhihua; Fiordeliso, James J.; Jiang, Weiqin; Zhang, Xuqing
Patent: US2005/250741 A1, 2005 ;
Location in patent: Page/Page column 58-59 ;
反应条件
1: 4-amino-5-iodo-2-trifluoromethyl-benzonitrile With potassium tert-butylate in tetrahydrofuran
T=0°C; 0.333333 h;
2: methanesulfonyl chloride in tetrahydrofuran
T=0 - 20°C;
参考文献
Lanter, James C.; Sui, Zhihua; Fiordeliso, James J.; Jiang, Weiqin; Zhang, Xuqing
Patent: US2005/245485 A1, 2005 ;
Location in patent: Page/Page column 58-59 ;
反应条件
1: pyridine / Heating
2: aq. NaOH / methanol
View Scheme
参考文献
Lanter, James C.; Fiordeliso, James J.; Allan, George F.; Musto, Amy; Hahn, Do Won; Sui, Zhihua
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 21 p. 5646 - 5649
反应条件
1: NIS; p-TsOH / methanol; tetrahydrofuran
2: pyridine / Heating
3: aq. NaOH / methanol
View Scheme
参考文献
Lanter, James C.; Fiordeliso, James J.; Allan, George F.; Musto, Amy; Hahn, Do Won; Sui, Zhihua
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 21 p. 5646 - 5649
