5-(羟基氨基)-2-吡啶羧酸合成路线 （共 4 条）
反应条件
hydrogen; nickel in methanol
0.75 h; Yield given;
参考文献
Oehlke, J.; Schroetter, E.; Dove, S.; Schick, H.; Niedrich, H.
Pharmazie, 1983 , vol. 38, # 9 p. 591 - 596
反应条件
1: 1.) 48 percent HBr, Br2; 2.) NaNO2 / 1) 30-40 deg C; 2) -5 deg C, H2O; 10-15 Deg C, 90 min.; 3) 40 deg C. 15 min
2: dimethylsulfoxide / 0.08 h / 180 °C
3: 54 percent / HCl / 1.5 h / Heating
4: H2 / Raney-Nickel / methanol / 0.75 h
View Scheme
参考文献
Oehlke, J.; Schroetter, E.; Dove, S.; Schick, H.; Niedrich, H.
Pharmazie, 1983 , vol. 38, # 9 p. 591 - 596
反应条件
1: dimethylsulfoxide / 0.08 h / 180 °C
2: 54 percent / HCl / 1.5 h / Heating
3: H2 / Raney-Nickel / methanol / 0.75 h
View Scheme
参考文献
Oehlke, J.; Schroetter, E.; Dove, S.; Schick, H.; Niedrich, H.
Pharmazie, 1983 , vol. 38, # 9 p. 591 - 596
反应条件
1: 54 percent / HCl / 1.5 h / Heating
2: H2 / Raney-Nickel / methanol / 0.75 h
View Scheme
参考文献
Oehlke, J.; Schroetter, E.; Dove, S.; Schick, H.; Niedrich, H.
Pharmazie, 1983 , vol. 38, # 9 p. 591 - 596
